"Abstract
... The aim of this article is to assess, on the basis of the available scientific literature, the risk of developing haematopoietic cancers after modRNA vaccination, and to investigate the potential genetic mechanisms involved in the pathogenesis of disease...
Introduction
... Several authors have expressed their concerns regarding the safety of mRNA vaccines against COVID-19, which are technically prodrug gene therapies encased in lipid nano particles (LNPs), rather than natural naked mRNA. The LNPs allow for unfettered access through most tissues and organs including the brain and the bone marrow...
In parallel to the rollout of the genetic vaccines, an increase in excess mortality is being reported in several countries worldwide. According to a recent study performed in Japan, the age-adjusted death rates for leukaemia, breast, pancreatic, and lip/oral/pharyngeal cancers increased significantly in 2022 after a large portion of the Japanese population had received the third dose of the modRNA vaccine, as compared to 2020, the first year of the pandemic, when no mass global genetic vaccinations were given. Likewise, a study aimed to estimate the excess mortality in Germany for the years 2020-2022, showed that in 2020, there were approximately 4,000 excess deaths, while in 2021 and 2022, there were approximately 34,000 and 66,000 excess deaths; respectively. The authors conclude that something must have happened in spring 2021 that led to a sustained increase in mortality.
Dr. Ute Kruger, a prominent physician and researcher at Lunds University in Sweden, with 25 years of experience in pathology and oncology, has recently proposed a theory that the genetic vaccines may be causing aggressive tumours that she named 'Turbo Cancers'...
[G]ene therapy has long been known to bear an oncogenic risk due to the phenomenon of insertional mutagenesis...
Discussion
Potential Carcinogenic Mechanisms Induced by COVID-19 modRNA Vaccines: Several mechanisms have been proposed by which the current modRNA COVID-19 vaccines may exert a carcinogenic effect, inducing both de novo tumour formation and the recurrence of neoplastic diseases in remission. It is also evident, that the genetic material and the vaccine derived spike protein have a significant impact on the immune system and may compromise immune surveillance against altered cellular clones in a manner that could lead to cancer.
The main alterations induced by modRNA COVID-19 vaccines reported in literature, that may have an oncogenic outcome are listed below:
(i) The alteration of the inhibitory immune checkpoint mediated by the programmed cell death protein 1 (PD-1, CD279), which is primarily found on... immune cells. The overexpression of the programmed death-ligand 1 (PD-L1), observed in vaccinated individuals, leads to T-cell immunosuppression, impairing cancer surveillance.
(ii) The interaction between the S2 subunit of the spike protein and the oncosuppressor proteins p53, BRCA1, and BRCA2, which regulate downstream genes in response to numerous cellular stress and play a crucial role in preventing cancer.
(iii) The impairment in type I interferon (IFN) signalling, which play essential roles in inflammation, immunomodulation, tumour cell recognition, and T-cell responses. Differential gene expression analysis of peripheral dendritic cells revealed dramatic upregulation of type I and type II IFNs in COVID-19 patients, but not in vaccinees. All this supports the possibility that COVID-19 genetic vaccines actively suppress the production of type I IFN which play [sic] a fundamental role in the immune reaction in response to multiple stressors, especially viral infections and tumours...
(iv) Increased Transforming Growth Factor Beta (TGF-β) Production. The interaction between the SARS-CoV-2 spike protein and the angiotensin-converting enzyme 2 (ACE2) induces TGF-β release by cells... promoting epithelial-mesenchymal transition (EMT). This process could explain the particular rapidity of onset and evolution of tumour forms arising following the administration of the COVID-19 genetic vaccines...
(v) The presence of LNP-encapsulated DNA contamination originating from residual plasmid DNA from DNA plasmids used during the manufacturing process of the Pfizer/BioNTech and Moderna modRNA genetic vaccines."
Preprint; case report
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