A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination

“Significance Statement: Several reports have described glomerular disease relapse after coronavirus disease 2019 (COVID-19) vaccination, but without proper controls, determining whether this association is real or due to chance is not possible. In this population-level cohort of 1105 adult patients with stable glomerular disease, a first dose of a COVID-19 vaccine was not associated with relapse risk; however, receiving a subsequent vaccine dose was associated with a two-fold higher risk of relapse.”