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Fereshteh Yazdanpanah, Pooya Iranpour, Sara Haseli, Maryam Poursadeghfard, and Fatemeh Yarmahmoodi
March 26, 2022
Radiology Case Reports

"Background

Acute disseminated encephalomyelitis (ADEM) is an intense disorder identifies [sic] by multifocal demyelinating white matter in the central nervous system (CNS). Dispersed neurologic signs in harmony with geographic distribution in the CNS, which are observed in imaging examination, confirm the condition. There are some pieces of evidence that vaccinations may provoke autoimmune demyelination. Previous studies revealed that ADEM events were linked with immunization for several infectious agents such as influenza, varicella, measles, mumps, rubella, tetanus, diphtheria, pertussis, and hepatitis B... Besides all the positive aspects of the COVID-19 vaccines, some adverse effects were observed, that based on reports, ADEM is one of them. Here, we report a case with signs, and symptoms of ADEM diagnosed after COVID-19 vaccination...

Discussion

Several neurologic complications have been reported following COVID-19 vaccination, many of which are of autoimmune nature.  These include GBS [Guillain–Barré syndrome], exacerbation of multiple sclerosis (MS), and other demyelinating disorders including ADEM, Transverse myelitis, and neuromyelitis spectrum disorders. 

We reported a patient with progressive weakness and dysphagia a few days after receiving is [sic] 1st dose of Sinopharm vaccine. The constellation of the clinical examination, laboratory findings, and imaging led to the diagnosis of ADEM."

See also this letter to the editor disputing the ADEM diagnosis: https://pmc.ncbi.nlm.nih.gov/articles/PMC9174925/

document
adverse events,clinical cases,COVID-19,neurological disorders,vaccines