"In this study, we used C57BL/6N mice at 6–8 weeks as young mice and 12 months as aged mice to investigate age-associated SARS-CoV-2 pathogenesis, re-infection, and vaccine breakthrough infections using our recently characterized wild-type mice infection model... [A]fter two doses of COVID-19 mRNA vaccination, abundant infectious virus titre was still readily retrieved from the NT of aged mice upon virus challenge, indicating that the mRNA vaccination-induced immune responses incompletely protected aged mice from SARS-CoV-2 infection."
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