"Key Results:
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In a retrospective study of 700 patients vaccinated against SARS-CoV-2 and 303 nonvaccinated patients who underwent PET/CT for indications other than myocarditis, patients who received their second vaccination 1–180 days before imaging showed higher myocardial fluorine 18 (18F) fluorodeoxyglucose (FDG) uptake (median standardized uptake value [SUVmax] range, 4.6–5.1 g/mL [IQR, 2.9–8.6 g/mL]) than nonvaccinated patients (median SUVmax, 3.3 g/mL [IQR, 2.5–6.2 g/mL]; range, P < .001 to P = .001).
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Myocardial 18F-FDG uptake was higher in vaccinated patients regardless of sex or patient age compared with corresponding nonvaccinated groups.
Introduction
... Cardiac MRI and fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT imaging have been routinely used in the noninvasive diagnosis of myocardial inflammation of diverse origin, including viral myocarditis, cardiac sarcoidosis, and cancer therapy–related cardiac dysfunction. Good agreement has been reported between late gadolinium enhancement or T2 hyperintensity on cardiac MRI scans and 18F-FDG uptake on PET scans in patients suspected of having myocarditis."
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