"Herpes zoster (HZ), which is reactivation of the varicella zoster virus (VZV), is associated with older age, use of immunomodulatory drugs, trauma, family history, and other comorbidities...
We performed a systematic search within PubMed, EMBASE, and Web of Science for relevant publications from inception to November 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines... COVID-19 vaccination was associated with a significantly increased risk of HZ (OR, 1.32; 95% CI, 1.09-1.62, P = .006) compared with controls...
The mechanism underlying the link between COVID-19 vaccination and HZ remains elusive; however, vaccination-induced immunomodulation has been proposed. Vaccine-induced massive shift of CD8+ T cells and CD4+ helper T cells may cause temporary inability to suppress latent VZV..."
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