"Abstract ... We report three cases of Guillain-Barre Syndrome [GBS] and one case of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), presenting to a Tasmanian hospital, and review 15 other reported cases and discuss likely immunopathology. Nearly all reported cases of post-COVID-19 vaccination inflammatory demyelinating polyneuropathy are linked to AstraZeneca vaccination and a variant with bifacial weakness is the most reported form of GBS globally ...
Introduction ... Herein, we report four cases of inflammatory demyelinating polyneuropathy presenting to the same hospital in northern Tasmania 1–3 weeks following ChAdOx1 nCoV-19 vaccination (AstraZeneca vaccine, AZ) ...
Cases: Over the course of six weeks, four individuals presented with Inflammatory Demyelinating Polyneuropathy (IDP), one with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and three with GBS, commencing one to three weeks after receiving the AZ vaccine. These included three males (51, 66 and 72 years) and one female (65 years). All of them developed lower back pain followed by progressive ascending paraesthesia, predominantly proximal paraparesis or quadriparesis and areflexia. Two developed facial weakness. Two progressed to respiratory failure requiring mechanical ventilation ...
Discussion ... In conclusion, an increasing number of case reports highlight the occurrence of inflammatory demyelinating polyneuropathy following administration of the AstraZeneca COVID-19 viral vector vaccine, emphasizing the need for vigilance regarding this specific adverse effect. Most reported cases involve a variant of GBS with bifacial weakness and respiratory failure. A potential link between GBS and AstraZeneca vaccine cannot be excluded at this time and indeed seems highly likely."
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