"Abstract
When an antigen stimulates the immune system, specific T regulatory (Treg) and T effector (Teff) subpopulations develop from naïve T cells. An imbalance between Treg and Teff cells can lead to either cancer or autoimmunity. Treg cells are beneficial in that they protect from autoimmunity. However, they suppress the immune response to tumors. In this review, we analyze Treg responses after SARS-CoV-2 mRNA vaccination and find distinct pathological responses under differing conditions...
Conclusion
The vaccines typically induce an intense IgG [immunoglobulin G] antibody response due to the toxicity of the spike protein, along with an extreme inflammatory response through cytokine release by T cells, and, ultimately, the potential for autoantibodies to attack the tissues through recognition of non-self spike protein on the cell surface. Because a natural infection is replaced by an abnormal situation in which human cells are producing large quantities of spike protein, the type I IFN response is suppressed. Normally, this response to double-stranded viral RNA induces the clonal expansion of a pool of Treg cells, but also keeps them suppressed until the viral load has sufficiently subsided. The mRNA in the vaccines is resistant to breakdown and concealed from the immune system due to its N1-methylpseudouridine replacements and humanized code. This causes an unnatural and often inappropriate immune response, where the consequences are highly dependent on the prior immune state of the vaccinated individual, particularly with respect to their Treg cell population. Some of the activated DCs return to the thymus and induce a response that damages the thymic epithelium and accelerates thymic involution, leading to inflammaging and immunosenescence. This can also induce a life-threatening macrophage activation syndrome (hemophagocytic lymphohistiocytosis), as was observed in several case studies on the mRNA vaccines. Repeated booster vaccination can lead to the development of self-tolerance to the spike protein, which may make the person less resistant to the virus than a fully unvaccinated person. Moreover, iatrogenic autoimmunity raised though molecular mimicry across recombinant SARS-CoV-2 spike protein epitopes from mRNA vaccines that attack the host immune system can be responsible for immune defects in the mRNA vaccinated individuals. This is a sound clinical explanation for the post-mRNA myocarditis cases that have been investigated and is readily occurring in other infectious diseases."
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