Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature

"Case Report: A 56-year-old white male with no significant previous history of medical conditions, but with a family history of malignancy, (mother had lung cancer due to smoking), presented with a massive and aggressively infiltrating basaloid-featured cancer in the right side of his face that rapidly evolved, ultimately ending in the patient's death. Symptoms began four days after his first mRNA vaccination (Pfizer), when he presented with severe right-sided temporal pain spreading to the temporomandibular (TM) joint ... Two months later, and as the condition worsened, the patient was diagnosed as suffering from right-sided trigeminal neuralgia and cranial nerve VII palsy ... Another two months later the patient was showing progressive wasting and loss of weight (12 kg) with progressing facial palsy symptoms. Four months after that - now 8 months post-mRNA injection - the patient showed increased temporal pain, deafness in the right ear, progressive wasting, inability to open the right eye, inability to open the right side of his mouth, vertigo, and limb weakness. A total paralysis of the right face was recorded with increased pain, swelling of the face on the right side, change of skin color to purple, and increased vascularity ...

The patient's family doctor recommended a computerized tomography (CT) brain scan and biopsy. The CT scan revealed a diffuse tumor of the right parotid gland (both superficially and in the deep portion), with swelling ... Biopsy revealed multiple infiltrations of basaloid type cell islands within the zygomatic, temporomandibular joint, optic nerve, fifth cranial nerve, and greater auricular nerve (data not shown but histology report is provided in supplementary information). The tumor cells had no connection to the basal cells or other layers of the epidermis. The infiltrations of cancer cells were extensive, and therefore the margins throughout the periphery of the tumor were not clear. Hence, surgical excision of the tumor was not considered a viable option. The patient's condition was not treated by any other means apart from morphine administration, and ultimately the patient passed away 4 months after the biopsy ... 

Discussion ... Overall, the short time frame and extremely invasive characteristics of BCC metastases in our patient suggest that immune system disturbances by the mRNA anti-COVID-19 vaccination may have led to the accelerated progression of the disease. The patient's initial presentation with facial palsy typical of BP served to conceal the underlying malignancy. Had an accurate diagnosis been made sooner, it is possible that an earlier intervention could have prevented this tragic outcome ... 

Conclusion ... Our group has previously published evidence that the mRNA injections should be expected to suppress innate immunity and thus promote carcinogenesis, primarily through suppression of type I interferon and the multiple downstream repercussions of that suppression (Seneff et al., 2022). Other research has shown the upregulation of PD-L1 in immune cells shortly after mRNA vaccination. This ligand has been shown to suppress the ability of T cells to attack tumors. In closing, it is interesting to note that a therapy that stimulates IFN-α production has shown a high degree of efficacy in the treatment of basal cell carcinoma (Schulze et al., 2005; Singal et al., 2016). The success of this therapy against BCC supports the immune-based model of enhanced malignancy we outline in this paper and points toward additional therapeutic avenues should similar malignancies arise in other patients, subsequent to an mRNA injection."