"Abstract: Lutein, a plant-derived thophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein is beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, and is beneficial for liver, kidney, and respiratory health. Lutein protects against oxidative and nitrosative stress, both of which play a major role in long COVID and mRNA vaccination injury syndromes. Lutein is an important natural agent for therapeutic use against oxidative and nitrosative stress in chronic illnesses such as cardiovascular and neurodegenerative diseases and cancer. It can also potentially inhibit spike protein-induced inflammation. Rich dietary supplementation of lutein, naturally derived in non-biodegradable Extra Virgin Olive Oil (EVOO), can most optimally be used against oxidative and nitrosative stress during post-COVID and mRNA vaccination injury syndromes...
10. Conclusions
Abundant evidence suggests that lutein could be an effective natural agent for use against chronic illnesses and long COVID and mRNA injury syndrome. Both conditions share the same pathogenic factor that provokes the disease, which is the SARS-CoV-2 spike protein. Due to the enhanced antioxidant properties of the molecule over the other xanthophylls and carotenoids, lutein can offer the most effective oxidation homeostatic balance, restore normal levels of NO [nitric oxide], and alleviate ROS/RNS [reactive oxygen species/reactive nitrogen species] imbalance. Particularly in long COVID and mRNA injuries, the levels of NO are altered, indicating nitrosative stress apart from oxidative stress. Although NO is not highly reactive, its derivatives generated with ROS reactions, such as peroxynitrate and N2O3, are highly reactive with larger biomolecules. Therefore, the impaired levels of NO can be a causative factor for arrhythmogenic cardiac failure. On these grounds, lutein’s adjuvant use for therapy has the potential to be lifesaving in these conditions. This is apart from lutein’s potential contribution to cardiovascular, kidney, liver, and neural-brain protection.
Furthermore, lutein can be useful against conditions of cognitive failure and dementia occurring from chronic inflammation in long COVID syndrome. Lutein’s antioxidant properties are complemented by its potential structural neutralization abilities against spike/ACE2 interactions. The spike protein is a long-lived circulating molecule in long COVID syndrome, and it is detected in autopsy cases of mRNA vaccination-induced cardiovascular complications that result in death. Therefore, lutein’s complementary docking abilities on the spike protein interface to the ACE2 receptor make it a molecule of high interest for preventing these conditions."
The first version of this paper was published on March 15, 2024:
Clinical rationale for dietary lutein supplementation in post COVID-19 and mRNA vaccine injury syndromes
https://doi.org/10.12688/f1000research.143517.1
© 2024 Kyriakopoulos AM et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.