"Conclusions: We propose curcumin as a therapeutic target for anti-corona virus drug development. In this work, we screened 14 ligands against SARS-CoV-2 structural and non-structural proteins and evaluate the binding affinity of curcumin to that of other known drugs that are commercially available. From the current study, it is evident that curcumin could play a major role in regulating the activity of
nucleocapsid and nsp10, both of which are indirectly related to the detection and processing of viral RNA. At very high concentrations, curcumin acts on the spike and membrane proteins and hence
invasion itself is difficult to achieve with the given solubility and plasma concentrations of curcumin. Further study on a combinatorial administration of drugs with curcumin would demonstrate if lesser
concentrations of curcumin could be effectual at the surface proteins. We hope that our studies provide an imperative role of curcumin as a potential therapeutic agent for COVID-19 treatment... "
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.