"Introduction
mRNA vaccines are associated with a risk of glomerular nephropathy, and relapse of minimal change disease has been reported after COVID-19 vaccination.
IgA nephropathy (IgAN) is a type of glomerulonephritis characterized by the deposition of IgA1-containing immune complexes. Previous case reports suggest that COVID-19 vaccination is associated with a relapse of IgAN ...
... Herein, we aimed to investigate the frequency of IgAN after COVID-19 mRNA vaccination by calculating RORs [reporting odds ratios] and ICs [information components] using the JADER [Japanese Adverse Drug Event Report] database...
Discussion
The results of this study suggest that COVID-19 vaccination increases the frequency of IgAN more than that of other drugs. In addition, females and young individuals show the tendency of an increased frequency of IgAN associated with COVID-19 vaccination compared to that of males and older individuals. Because the frequency of drug-induced nephritis was higher in males than in females, there might be different mechanisms in nephritis associated with COVID-19 vaccination and that associated with other drugs ... Although the JADER database does not include information regarding renal biopsy, most of nephritis cases associated with COVID-19 vaccination might be glomerulonephritis...
Conclusion
The analyses revealed that COVID-19 vaccination is associated with an increased incidence of IgAN. Monitoring of gross hematuria following COVID-19 vaccination is needed."
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