"Introduction
In this study, our goal is to present a strong Bayesian multivariate meta‑analysis model to examine the link between vaccine‑ related cardiovascular events in controlled studies, taking into account correlations between outcomes.
Methods
Objectives: The primary goal is to examine the possible presence of cardiovascular events, specifically myocardial infarction, CAD, arrhythmia, and stroke, linked to COVID‑19 vaccination... [W]e compared BNT162b2 and mRNA vaccines, with a focus on cardiovascular complications as a Secondary Analysis...
Search strategy: A thorough search of prominent electronic databases... was performed until October 22, 2023, to retrieve all relevant publications...
Bayesian multivariate and univariate results
Primary analysis... the overall odds of CAD [coronary artery disease] events in the vaccine group exceeded than [sic] the control group (OR, 1.70; 95% CrI: 1.11–2.57)...
Results based on vaccine type revealed a link between the BNT162b2 vaccine and an increased risk of myocardial infarction (OR, 1.87; 95% CrI: 1.22–2.89) and stroke (OR, 2.09; 95% CrI: 1.36–3.21)...
Examining the results by dose, irrespective of the vaccine type, revealed that the first dose was linked to a higher risk of arrhythmia (OR, 2.98; 95% CrI: 1.41–6.32) and stroke (OR, 3.40; 95% CrI: 1.98–1.98)...
Discussion
... Our primary analysis, conducted through Bayesian multivariate meta-analysis, uncovered notable insights regarding the impact of COVID-19 vaccines on cardiovascular health. Specifically, we found that the administration of COVID-19 vaccines, particularly BNT162b2, was associated with increased odds of CAD following the second dose ... Subgroup analysis revealed a significant increase in arrhythmia and stroke risk after the first vaccine dose, a rise in myocardial infarction and CVD [cardiovascular disease] risk post-second dose, and no significant association after the third dose ... Analysis by vaccine type indicated that the BNT162b2 vaccine was notably linked to increased risk for all events except arrhythmia. In contrast, the ChAdOx1 vaccine primarily affected arrhythmia risk, especially after the first dose, while other vaccines showed no significant effects ... "
© 2025 International Journal of Preventive Medicine
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