"Antibody-dependent enhancement (ADE) is an antibody-mediated increase of infection (ADE) which is a paradoxical reaction of the immune system during viral infection, when generally non-neutralizing antibodies facilitate and exacerbate infection. The ADE phenomenon is well known in veterinary medicine... The ADE phenomenon has been evoked for the Covid-19 vaccine but it was refuted. However, we think that the reasoning underlying the rebuttal of the possibility of an ADE effect for Covid-19 is questionable...
Firstly, the ADE phenomenon requires the presence of infected macrophages and circulating antibodies at the time of vaccination...
The COVID-19 vaccine transfection through body tissues distant from the injection site can cause numerous adverse effects, thrombosis and myocarditis in the first instance (the so called “spikeopathy”)...
Vaccine-induced cytokine changes could also promote the onset of myocarditis. Indeed, compared to nonvaccinated patients, asymptomatic patients who received their vaccination showed increased myocardial FDG [fluorodeoxyglucose] uptake on PET/CT. In addition, the direct toxic effects of the spike protein produced against the vascular endothelium which strongly expresses ACE2, the spike's target receptor, lead to inflammation, hypercoagulability and thrombosis. This is clinically expressed in myocardial infarction, cerebral thrombophlebitis and stroke. It is crucial to note that myocarditis has already been described in the literature in the context of thrombotic thrombocytopenic purpura, a thrombosis-inducing disease that can occur in the aftermath of an endothelial aggression and subsequent dysfunction. These remaining adverse effects are difficult to assess. Most have not been reported to the authorities, partly because some doctors have peremptorily stated that these events were not related to the vaccine...
Observation of peaks of Covid-19 contamination subsequent to mass vaccination initiation... allow us to suspect the presence of ADE phenomena... Our assertions have some limitations relating to Halstead and Katzelnick main argument that boils down to: 'In contrast to dengue virus, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages. Severe disease centers on older persons with preexisting conditions and not infants or individuals with previous coronavirus infections.' However, their argument that it was not epidemiologically nor pathologically observed is very weak in the light of the two signals factually observed : (a) the peak of contamination following mass vaccination initiation and (b) the results of statistical analysis of the IHU [institut hospitalo-universitaire] Méditerrannée data showing that vaccinated patients, without risk factors and comorbidities and with a disease condition necessitating hospitalization, had a statistically significant higher risk of experiencing ICU transfer or death compared with unvaccinated patients."
All articles published by Fortune Journals are Open Access, distributed under the terms of the Creative Commons Attribution License version 4.0.