“Abstract: The essentiality of zinc in humans was established in 1963. During the past 50 y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed... Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc… is very effective in decreasing the incidence of infection in the elderly. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent.”
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