March 24, 2025
Vaccines
"Abstract
Methods: ... Thirty female Wistar albino rats, aged 16–24 weeks, were randomly divided into three groups (n = 10): control, mRNA vaccine, and inactivated vaccine groups. Each vaccine group received two doses (on day 0 and day 28) at human-equivalent doses. Four weeks post-second vaccination, ovarian tissues were harvested for analysis...
Conclusions
This study is the first to evaluate the effects of mRNA and inactivated COVID-19 vaccines on ovarian follicles and ovarian reserve in a rat model. The findings demonstrate that both vaccines, particularly the mRNA vaccine, are associated with a reduction in ovarian reserve, characterized by depletion of the primordial follicle pool and increased follicular loss via apoptosis throughout folliculogenesis. However, these results should be interpreted cautiously, as preclinical models cannot be directly extrapolated to human reproductive health. Further longitudinal studies in human populations, including assessments of AMH [Anti-Müllerian hormone] levels and antral follicle counts, are necessary to validate these observations and determine their clinical significance."
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document
adverse events,COVID-19,reproductive system issues,vaccines