Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics

URL

https://onlinelibrary.wiley.com/doi/10.1002/iid3.639

Authors

Md. Sorwer Alam Parvez, Manash Kumar Saha, Md. Ibrahim, Yusha Araf, Md. Taufiqul Islam, Gen Ohtsuki, and Mohammad Jakir Hosen

Published Date

January 20, 2022

Publication

Immunity, Inflammation and Disease

Organization

Shahjalal University of Science & Technology (Bangladesh)

Key Excerpts

"2.7 Analysis of the effectiveness of promising drugs

We analyzed 10 promising drugs targeting the main (3CL) protease protein of SARS-CoV-2 including Nirmatrelvir, Ritonavir, Ivermectin, Lopinavir, Boceprevir, 13b, N3, GC-373, GC376, and PF-00835231...

From our study, Ivermectin showed the highest binding affinity, suggesting to be the most effective drug candidate against the Omicron variant."

Open Access: https://creativecommons.org/licenses/by/4.0/

Medium

document

Topics

COVID-19,ivermectin,medical treatments,pharmaceuticals