"Conclusion
This study screened apigenin, fisetin, kolaflavanone, and remdesivir as potential molecules that could mitigate/inhibit SARS-COV2 using in silico methodology and guide in the development of effective therapeutics to combat COVID-19. Kolaflavanone was observed to exhibit the highest binding affinity with the SARS-COV2 major protease (6LU7). All the three tested phytochemicals (apigenin, fisetin, kolaflavanone) showed more binding affinity with 6LU7 than remdesivir, an established antiviral drug. Binding of these phytochemicals to SARS-COV2 could inhibit or interfere [with] the pathogenesis of COVID-19 thereby preventing its cellular entry and proliferation. The pharmacodynamics and pharmacokinetics properties of the phytochemicals showed that they would be good drug candidates and the toxicological evaluations showed that these phytochemicals have relatively low or no toxic effect in human."
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