"Abstract
Key Clinical Message: Lymphadenopathy following recent immunization is usually regional. Generalized lymphadenopathy should arouse suspicion for alternative underlying pathology. Prostate adenocarcinoma should be considered in the differential diagnosis for malignancy in an elderly male patient. Metastatic prostate adenocarcinoma can have good prognostic outcomes if treatment is started promptly, even in the setting of widespread disease.
Generalized lymphadenopathy is commonly attributed to infectious causes or malignancy, often lymphoproliferative disorders...
2 Case Description
We present the case of a 70-year-old Hispanic male who presented to the urgent care clinic with left lower quadrant abdominal pain, nausea, headache, myalgia, and severe constipation. He had just received his fourth COVID booster vaccine the day prior and stated to have been asymptomatic prior to receiving the immunization...
3 Discussion
... It is likely that our patient had preexisting lymphadenopathy that he noticed only following immunization. To the best of our knowledge, this is the first case reported of a COVID vaccine booster uncovering lymphadenopathy leading to the diagnosis of metastatic prostate cancer... Interestingly, metastatic disease, advanced age, and male sex in patients with solid tumors are independent risk factors that have been shown to reduce antibody response following vaccination. Vaccine induced lymphadenopathy has been noted in patients with preexisting breast cancer and melanoma, with persistence of lymphadenopathy for more than 6 weeks in 29% of patients."
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