Need for validation of vaccination programs

"Abstract

Background: The risk of immunodeficiency associated with frequent messenger ribonucleic acid (mRNA) vaccinations has become increasingly evident, leading to the widespread discontinuation of additional doses, except in Japan.

Main body: Reevaluation of vaccination programs, including live-attenuated vaccines, is crucial. Recently, three cases of children who died a day after routine vaccination were reported in Japan. Despite detailed information, including autopsy findings, experts concluded that a causal relationship with vaccination could not be evaluated. This commentary highlights the challenges with mRNA vaccines and further discusses the need to reassess the efficacy and safety of vaccines that have already been approved...

1 Background

Growing evidence of immunodeficiency risks associated with frequent messenger ribonucleic acid (mRNA) vaccinations has led to the global discontinuation of additional doses, with Japan as the notable exception. The decrease in immunity can be caused by several factors, such as N1-methylpseudouridine, the spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. Subsequent studies showed that a significant increase in IgG4, which evades immunity, occurs in frequent vaccine recipients, contributing significantly to the elucidation of the mechanism of mRNA vaccine-induced immunodeficiency...

1.2 Questions on the efficacy and safety of currently approved vaccines

... It is worth considering whether the acquisition of immunity through vaccination, which prioritizes the production of one type of antibody (e.g., as seen with coronavirus vaccines), might inadvertently reduce the production of others. As many viruses and bacteria are transmitted through mucous membranes, the current method of directly injecting vaccines into the body bypasses natural immune pathways. As vaccines are administered to healthy individuals, their safety is paramount to ensure they do not contribute to disease or mortality...

1.3 Need for validation of vaccination programs and preventive measures

... Japan is the only country globally to have approved a self-amplifying RNA vaccine (commonly referred to as a replicon vaccine) at present (Dec. 17, 2024), and vaccination with this product has already commenced, sparking societal concern. It seems the Japanese public is now being inadvertently involved in clinical trials to gather data on vaccine safety and risks.

Globally, questioning vaccination has long been considered taboo, with strong social pressures to conform and be vaccinated. The aggressive promotion of the coronavirus vaccine through biased messaging remains vividly remembered. This atmosphere of conformity may partially explain the lack of significant progress in critically reviewing vaccination practices.

Numerous vaccines are currently under development, yet true vaccine advancement requires rigorous methodologies, including double-blind, placebo-controlled trials with long-term follow-up. Conducting such studies poses ethical challenges, particularly in an environment where vaccination is universally regarded as unequivocally beneficial."