"Methods: With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP database, including a) adolescents aged 12-15 years, and b) children aged 5-11 years and comparing individuals receiving i) first vaccination with unvaccinated controls and ii) second vaccination to single-vaccinated controls...
Results
Adolescents: Of 513,192 eligible adolescents who were registered at a TPP practice and received a BNT162b2 vaccination during the study period, 410,463 (80%) were matched with unvaccinated controls...
Children: Of 177,360 children eligible in the first vaccination group 141,711 (80%) were matched with unvaccinated controls...
Discussion
... COVID-19-related hospitalisation, and critical care attendance were rare in both adolescents and children and there were no COVID-19 related deaths. Whilst rare, all myocarditis and pericarditis events during the study period occurred in vaccinated individuals...
Findings in Context: ... The rates of heart inflammation (myocarditis and pericarditis) in under 18s reported by the UK Medicines and Healthcare products Regulatory Agency were 13 and 8 per million after first and second doses respectively, compared with our estimates of 27 and 10 per million respectively."
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