"Potential Antibody Dependent Enhancement (ADE) of Mers-CoV Infection
Antibody dependent enhancement (ADE) is a condition whereby non-neutralizing antibodies are produced following an infection or a vaccination, which enhance the infectivity of the subsequent infection (Kuzmina et al., 2018). ADE of viral infections have been reported for dengue virus, human immunodeficiency virus, influenza virus, other alpha and flaviviruses, SARS-CoV, and Ebola virus (Dutry et al., 2011; Kuzmina et al., 2018). Thus, ADE is a critical issue...
the ADE of SARS-CoV infection in human cells was only discovered 8 years after the virus was first identified in 2003 (Yip et al., 2011). Jaume et al. (2012) demonstrated that non-neutralizing antibodies induced by the full-length S protein of SARS-CoV facilitated the viral entry into host cells via a FcγR-dependent pathway."
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