What is cerebral venous sinus thrombosis? “Cerebral venous sinus thrombosis (CVST) occurs when a blood clot forms in the brain’s venous sinuses. This prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage.” (Source Johns Hopkins)
“Recent reports suggest a possible association between Ad26.COV2.S (Johnson & Johnson/Janssen) COVID-19 vaccination and cerebral venous sinus thrombosis (CVST). Estimates of postvaccination CVST risk require accurate age- and sex-specific prepandemic CVST incidence rates; however, reported rates vary widely. We compared the age- and sexspecific CVST rates after Ad26.COV2.S vaccination with the prepandemic CVST rate in the population…
Results: … The overall [prepandemic] age- and sex-adjusted CVST incidence was 2.34 per 100 000 person-years (PY)…
The overall incidence rate of post–Ad26.COV2.S vaccination CVST was 8.65 per 100 000 PY (95% CI, 5.88-12.28 per 100 000 PY) at 15 days, 5.02 per 100 000 PY (95% CI, 3.52-6.95 per 100 000 PY) at 30 days…”
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