Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study

URL

https://www.bmj.com/content/374/bmj.n1931

Authors

Julia Hippisley-Cox, Martina Patone, Xue W. Mei, Defne Saatci, Sharon Dixon, Kamlesh Khunti, Francesco Zaccardi, Peter Watkinson, Manu Shankar-Hari, James Doidge, David A. Harrison, Simon J. Griffin, Aziz Sheikh, and Carol A. C. Coupland

Published Date

August 26, 2021

Publication

BMJ (British Medical Journal)

Organization

University of Oxford (UK)

Key Excerpts

"Objective: To assess the association between covid-19 vaccines and risk of thrombocytopenia and thromboembolic events in England among adults.

Design: Self-controlled case series study using national data on covid-19 vaccination and hospital admissions...

Results: ... Secondary analyses found increased risk of CVST [cerebral venous sinus thrombosis] after ChAdOx1 nCoV-19 vaccination (4.01, 2.08 to 7.71 at 8-14 days), after BNT162b2 mRNA vaccination (3.58, 1.39 to 9.27 at 15-21 days), and after a positive SARS-CoV-2 test"

Open Access CC-BY

Medium

document

Topics

adverse events,COVID-19,mRNA,SARS-CoV-2 spike protein,vaccines,vascular system issues