“Discussion: The magnitude and quality of the immune memory response to SARS-CoV-2 will be critical in preventing reinfection. Here we undertook an assessment of SARS-CoV-2-specific T cell immune response at 6 months following primary infection in a unique cohort of healthy adults with asymptomatic or mild-to-moderate COVID-19… The major finding was that virus-specific T cells were detectable in all donors at this extended follow-up period …
The magnitude of T cell response was heterogeneous and may reflect diversity in the profile of T cell immunity during acute infection. A striking feature was that the magnitude of cellular immunity by ELISPOT was 50% higher in donors who had experienced symptomatic infection. This demonstrates that the initial ‘set point’ of cellular immunity established following acute infection is maintained for at least 6 months.”
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