Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

URL

https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4

Authors

Takuya Sekine, Andre Perez-Potti, Olga Rivera-Ballesteros, Kristoffer Strålin, Jean-Baptiste Gorin, Annika Olsson, Sian Llewellyn-Lacey, Habiba Kamal, Gordana Bogdanovic, Sandra Muschiol, David J. Wullimann, Tobias Kammann, Johanna Emgård, Tiphaine Parrot, Elin Folkesson, Karolinska COVID-19 Study Group, Olav Rooyackers, Lars I. Eriksson, Jan-Inge Henter, Anders Sönnerborg, Tobias Allander, Jan Albert, Morten Nielsen, Jonas Klingström, Sara Gredmark-Russ, Niklas K. Björkström, Johan K. Sandberg, David A. Price, Hans-Gustaf Ljunggren, Soo Aleman, and Marcus Buggert

Published Date

August 14, 2020

Publication

Cell

Organization

Karolinska Institutet (Sweden)

Key Excerpts

“Summary: SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19… Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.”

Medium

document

Topics

natural immunity