Correspondence article
"SARS-CoV-2-induced multi-lineage neural cell dysregulation has been documented. SARS-CoV-2 infection elevates neuroinflammation, alters brain structure, leads to abnormal accumulation of neurodegenerative amyloid-β (Aβ) and phosphorylated tau, and increases the risk of cognitive impairment in COVID-19 patients...
To evaluate long-term impact of SARS-CoV-2 infection to the brain...hACE2 [humanized ACE2] transgenic mice... were intranasally infected with a single low dose...of prototyped SARS-CoV-2 and maintained for up to 30 days post infection...
[W]e have identified S-S2 subunit as a γ-secretase modulatory protein and revealed a previously unknown mechanistic insight into COVID-19-related neuropathological sequelae... The Spike protein could function as an immune switch to increase γ-secretase activity and Aβ production and contribute to neurological changes in COVID-19 patients."
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