Index Entries

Sara Eslait-Olaciregui, Kevin Llinás-Caballero, David Patiño-Manjarrés, Thomas Urbina-Ariza, Juan Fernando Cediel-Becerra, and Camilo Alberto Domínguez-Domínguez
May 21, 2023
Therapeutic Advances in Drug Safety
Universidad del Rosario (Colombia)

"Abstract ... There is some epidemiological evidence linking COVID-19 vaccines to cerebral venous sinus thrombosis, arterial ischemic stroke, convulsive disorder, Guillain–Barré syndrome, facial nerve palsy, and other neurological conditions. Cerebral venous sinus thrombosis has been associated with a thrombotic thrombocytopenia induced by the vaccine, similar to that induced by heparin, which suggests similar pathogenic mechanisms (likely involving antibodies against platelet factor 4, a chemokine released from activated platelets). Arterial ischemic stroke is another thrombotic condition observed among some COVID-19 vaccine recipients. Vaccine-induced convulsive disorder might be the result of structural abnormalities potentially caused by the vaccine or autoimmune mechanisms. Guillain–Barré syndrome and facial nerve palsy may also be linked to the immunization event, possibly due to immune mechanisms such as uncontrolled cytokine release, autoantibody production, or bystander effect ...

Methods: We present a narrative review of the literature regarding the serious neurological complications of COVID-19 vaccines. We searched international biomedical journal databases, such as MEDLINE (PubMed) using the following Medical Subject Headings (MeSH) terms and their synonyms: (‘adverse effects’ OR ‘Drug-Related Side Effects and Adverse Reactions’) AND ‘COVID-19 Vaccines’ AND (‘Neurologic Manifestations’ OR ‘Nervous System’). This search included evidence published until August 2022..."

document
adverse events,COVID-19,neurological disorders,vaccines