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F. Konstantin Föhse, Büsra Geckin, Martijn Zoodsma, Gizem Kilic, Zhaoli Liu, Rutger J. Röring, Gijs J. Overheul, Josephine van de Maat, Ozlem Bulut, Jacobien J. Hoogerwerf, Jaap ten Oever, Elles Simonetti, Heiner Schaal, Ortwin Adams, Lisa Müller, Philipp Niklas Ostermann, Frank L. van de Veerdonk, Leo A.B. Joosten, Bart L. Haagmans, Reinout van Crevel, and Mihai G. Netea
May 6, 2021
Radhoud University Medical Center (Netherlands)

"Our data show that the BNT162b2 vaccine induces effects on both the adaptive and innate branches of the immune system. Intriguingly, the BNT162b2 vaccine induces significant changes in interferon production, and this needs to be studied in more detail: in combination with strong adaptive immune responses, this could contribute to a more balanced inflammatory reaction during infection with SARS-CoV-2 or other pathogens. Our findings need to be confirmed by conducting larger cohort studies with populations with diverse backgrounds, while further studies should investigate the incidence of heterologous infections after BNT162b2."

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breakthrough cases,COVID-19,vaccines,mRNA,natural immunity