A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

URL

https://journals.asm.org/doi/10.1128/JVI.06048-11

Authors

Meagan Bolles, Damon Deming, Kristin Long, Sudhakar Agnihothram, Alan Whitmore, Martin Ferris, William Funkhouser, Lisa Gralinski, Allison Totura, Mark Heise, and Ralph S. Baric

Published Date

December 1, 2011

Publication

Journal of Virology

Organization

University of North Carolina at Chapel Hill

Additional Information

This work was supported by grants from the National Institutes of Health, Division of Allergy and Infectious Diseases (AI075297, U54AI080680, and U54AI081680-01), and the UNC-CH Medical Science Training Program (T32GM008719 [M.B.]).

Medium

document

Topics

antibody dependent enhancement (ADE),vaccine systemic and virological concerns