"Introduction
... [A] significant body of research has been dedicated to investigating the adverse outcomes associated with SARS-CoV-2 vaccines. These investigations range from individual case reports to comprehensive systematic reviews and cover a variety of adverse events including myocarditis, thrombotic events, skin reactions, dermatologic side effects, late-onset myasthenia gravis, and hypermetabolic lymph nodes.
Although most of these reactions are mild and temporary, certain conditions such as myocarditis and thrombotic events have drawn particular scrutiny due to their severity. Evidence suggests that cases of myocarditis and pericarditis are more likely to occur within 14 days post-vaccination, predominantly following the second dose and especially in younger males. These adverse effects have been observed across various vaccine platforms, including ChAdOx1, BNT162b2, and mRNA-1273. Furthermore, Thrombosis with Thrombocytopenia Syndrome (TTS) following administration of Vaxzevria and Jcovden vaccines has been reported, with a significant number of cases being fatal...
[O]ur study employs an overview and meta-analysis to delve into the patient characteristics, symptoms, laboratory findings, and mortality rates associated with adverse reactions to COVID-19 vaccines...
Discussion
This study offers a comprehensive analysis of adverse outcomes following SARS-CoV-2 vaccination, based on a systematic review of studies published up to February 2023. We found that the most prevalent adverse effects include myocarditis, thrombotic events, skin reactions, potential fertility issues, Guillain-Barre Syndrome, dermatologic side effects, late-onset myasthenia gravis, hypermetabolic lymph nodes, and renal complications...
We observed that thrombosis and myocarditis were among the most severe adverse outcomes...
A further comparative analysis on myocarditis or thrombotic events in mRNA vs vector-based vaccines revealed notable differences. The myocarditis rate post-vector vaccines was 6%, in contrast to 61% post-mRNA vaccines. Safety concerns regarding mRNA and vector vaccines have been the subject of debate, with reports of myocarditis following mRNA COVID-19 vaccinations by the CDC and VAERS...
Conversely, our data showed that 91% of thrombosis cases were associated with vector vaccines."
© 2024 Yang, Tian, Shen and Li.
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