"1. Introduction
... Reports on serious complications after mRNA vaccination should also be noted. Fatal reactions including thrombotic thrombocytopenia, myocarditis/pericarditis, rhabdomyolysis, and anaphylaxis were noted in a previous review article. Both central and peripheral nervous systems have also been reported to be involved in adverse reactions to mRNA vaccines...
[T]here is still insufficient information regarding the persistent symptoms that occur after vaccination. The aim of the present study was to determine the clinical characteristics of patients suffering from persistent symptoms after mRNA vaccination and to explore serious conditions based on our clinical experiences in a specialized clinic for vaccination-related adverse events...
2.2. Collection of Clinical Data
Medical records for 164 patients who visited the [Okayama University Hospital] clinic during the period from April 2021 to March 2023 were carefully reviewed...
3. Results
... Data for 127 patients who visited our clinic were obtained, and descriptive analysis was performed for 121 patients. Detailed clinical courses of six patients with serious complications are also shown...
4. Discussion
... The proportion of female patients in our study was 1.7 times higher than that of male patients (63.6% vs. 36.4%). The large proportion of female patients in our study is in agreement with the results of a population-based study showing that the incidence of neurological autoimmune diseases following vaccinations against SARS-CoV-2 was 3.2 times higher in women in Germany...
In the present study, sensory impairment was the most frequent symptom (in 34 (28.1%) of the 121 patients). Several studies have shown neurological symptoms after SARS-CoV-2 vaccination. The reported neurological symptoms include both central nervous system disorders, such as headache, venous sinus thrombosis, ischemic stroke, intracerebral hemorrhage, subarachnoid bleeding, reversible cerebral vasoconstriction syndrome, vasculitis, pituitary apoplexy, Susac syndrome, encephalitis, meningitis, demyelinating disorders, transverse myelitis, and epilepsy, and peripheral nerve disorders (Guillain–Barre syndrome), Parsonage–Turner syndrome (plexitis), small fiber neuropathy, myasthenia, myositis/dermatomyositis, and rhabdomyolysis have been reported...
[S]ensory impairment was the most frequent symptom persisting for 1–3 months followed by symptoms that persisted for 6 months or more...
Serious Complications after SARS-CoV-2 Vaccination
A principal researcher (K.T.) and co-researchers confirmed cases with serious complications that had severe inflammation, required the use of prednisolone, or had a difficult curable status with persistent symptoms. We included six cases according to the criteria."
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