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Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects

https://www.biorxiv.org/content/10.1101/2024.04.16.589801v1.full 

Serena Omo-Lamai, Yufei Wang, Manthan N. Patel, Eno-Obong Essien, Mengwen Shen, Aparajeeta Majumdar, Carolann Espy, Jichuan Wu, Breana Channer, Michael Tobin, Shruthi Murali, Tyler E. Papp, Rhea Maheshwari, Liuqian Wang, Liam S. Chase, Marco E. Zamora, Mariah L. Arral, Oscar A. Marcos-Contreras, Jacob W. Myerson, Christopher A. Hunter, Andrew Tsourkas, Vladimir Muzykantov, Igor Brodsky, Sunny Shin, Kathryn A. Whitehead, Peter Gaskill, Dennis Discher, Hamideh Parhiz, and Jacob S. Brenner
April 18, 2024
University of Pennsylvania

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved.

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adverse events,COVID-19,lipid nanoparticles,vaccine composition,vaccine systemic and virological concerns,vaccines