"Abstract
Rationale: ...[T]here has been a steady increase in the number of patients presenting with nephrotic syndrome and acute kidney injury after the administration of COVID-19 vaccine....
Discussion
... We report a case of de novo MCD with AKI after the first dose of Pfizer-BioNTech COVID-19 vaccine...
This case further supports the temporal association between COVID-19 vaccine (in this case Pfizer-BioNTech as with most of the previous reported cases) and the new onset of MCD [minimal change disease] in association with AKI. Acute kidney injury is a consistent feature reported in most of the cases. Although a causal association cannot be definitively confirmed, clinicians and pathologists should be aware of MCD presenting with nephrotic syndrome as a potential side effect...
While the majority of the de novo MCD cases have been reported post Pfizer-BioNTech administration, cases associated with Moderna COVID-19 mRNA vaccination and with the non-mRNA-based AstraZeneca vaccine have also occurred. With prompt initiation of steroid therapy, complete remission of nephrotic syndrome and AKI can be achieved in the majority of cases."
© The Author(s) 2021.
This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).