"Findings: Between Jan 5, 2021 (date of second-dose vaccine roll-out) and May 12, 2022, 104 500 individuals vaccinated with BNT162b2 and 61 955 individuals vaccinated with mRNA-1273 were matched to unvaccinated individuals with a documented primary infection. During follow-up, 7123 SARS-CoV-2 infections were recorded in the BNT162b2-vaccinated cohort and 3583 reinfections were recorded in the matched natural infection cohort. 4282 SARS-CoV-2 infections were recorded in the mRNA-1273-vaccinated cohort and 2301 reinfections were recorded in the matched natural infection cohort...
Discussion: Our results showed that previous natural infection was associated with an overall lower incidence of SARS-CoV-2 infection than mRNA primary-series vaccination, including among individuals aged 50 years or older. Natural infection was also associated with lower incidence of severe COVID-19 than mRNA vaccination; however, severe COVID-19 was rare for both the natural infection and vaccinated cohorts."
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.