SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

“Added value of this study: In this context, we investigated, the adaptive immune response developed during SARS-CoV-2 infections in 203 recovered patients experiencing a full spectrum of disease severity, from asymptomatic infections to severe cases requiring hospitalization. The analysis of both binding and neutralization capacity of participant antibodies, alongside CD8+ T-cell responses, towards multiple SARS-CoV-2 epitopes, provides a broad characterization of the adapted response during primary virus infection. We found that the vast majority of recovered individuals have clearly detectable and functional SARS-CoV-2 spike specific adaptive immune responses, despite diverse disease severities…

Discussion: … Overall, our results show that the majority of patients developed a robust and broad both humoral and cellular immune response to SARS-CoV-2.”