"Abstract
Purpose: ...The objectives of this study are to investigate the distinctive structural features of SARS-CoV-2 S protein, its essential role in pathogenesis, and its use in the development of potential therapies and vaccines...
Methodology: A literature review was conducted to summarize, analyze, and interpret the available scientific data related to SARS-CoV-2 S protein in terms of characteristics, vaccines development and potential therapies...
mRNA-1273 (Moderna vaccine)
... The safety of mRNA vaccine was investigated including local and systemic adverse effects, where moderate-to-severe systemic side effects have been reported. Notably, the most common systemic adverse effects following the first dose injection were headache, in addition to arthralgia, myalgia, chills, nausea and vomiting. Overall, longitudinal clinical data are critically required to further assess the immunogenicity and safety of the Moderna vaccine...
Conclusion
... [T]here is well-established evidence that SARS-CoV-2 S protein plays vital role in virus pathogenesis and transmission, making it an important target for the development of therapeutics and vaccines...the deep understanding of S protein including its structural features, binding interactions, and mutations...promotes the discovery of novel potential applications in diagnosis and immunotherapy."
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