"We have hypothesized that similar to viruses such as HIV-1 (Fackler et al., 2007), SARS-CoV-2 may target IS [immune synapse] assembly and function as a means to escape CTL [cytotoxic T lymphocyte]-mediated killing. We provide evidence that Spike suppresses IS assembly in CTLs, leading to impaired cytotoxicity and cytokine production."
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