"Abstract
Background and Purpose: The aim of this paper is to extensively review published literature regarding post-COVID-19 vaccination neurological complications and characterize neuroimaging findings from three case presentations for early diagnosis and treatment...
Results: The literature review yielded several neurological complications post vaccination, including cerebral sinus venous thrombosis, transverse myelitis, Guillain-Barré Syndrome and optic neuritis, to name a few ...
1. Introduction
... Here in, we report a case series of transverse myelitis, chronic inflammatory demyelinating polyneuropathy and optic neuritis following use of Moderna, Johnson & Johnson’s and Pfizer-BioNTech COVID-19 vaccination, respectively. Furthermore, we briefly provide a review of the literature on clinical management and the relevance of neuroimaging in patients presenting with post-COVID vaccination neurological sequelae ...
4. Discussion
... Adverse reactions can occur with the administration of any vaccine. Several neurological manifestations following the COVID-19 vaccination have been reported. The National Board of UK and Vaccine Adverse Event Reporting System (VAERS), which is managed by the CDC and FDA, has reported transverse myelitis, GBS, Bell’ palsy, cerebral venous sinus thrombosis, and stroke following administration of Pfizer-BioNTech BNT162b, Moderna mRNA-1273 Oxford-AstraZeneca and Janssen (Johnson & Johnson) vaccine (Table 2 and Table 3). Complications and treatment outcomes of complications were further explored ...
5. Conclusions
We conducted a thorough literature search regarding post-COVID 19 neurological complications. We also presented a case series of three patients with vastly different neurological complications post-COVID 19 vaccination. The goal is to understand the importance that neuroimaging plays in the early detection, diagnosis, and subsequent treatment of severe conditions, including cerebrovascular accidents, thrombosis, and demyelinating inflammatory processes. Further studies and data are required to provide a substantial basis and formulation for guidelines on the early identification and neuroimaging study on post-COVID-19 vaccination-related neurological manifestation."