"Abstract
... Herein, we report a rare presentation of TAFRO [thrombocytopenia (T), anasarca (A), fever (F), reticulin myelofibrosis, renal dysfunction (R), and organomegaly (O)] syndrome triggered by the COVID-19 vaccine with a fatal clinical course. A 42-year-old Japanese man presented to our hospital complaining of fever lasting for 2 weeks that occurred a day after receiving the BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine. The patient had a low platelet count, ascites, reticulin myelofibrosis, renal failure, and lymphadenopathy and was diagnosed with TAFRO syndrome. Despite administering several immunosuppressive drugs, the condition did not improve. The patient repetitively developed and eventually died of bacteremia caused by multidrug-resistant Klebsiella pneumoniae. We highlight the first reported case of TAFRO syndrome after COVID-19 vaccination.
3. Discussion
... Although the patient's symptoms occurred immediately after the administration of the vaccine, it is difficult to establish a causal relationship between the vaccine and TAFRO syndrome. We considered that the hyperinflammatory condition after the vaccine might have contributed to the syndrome."
© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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