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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3 

Alba Grifoni, Daniela Weiskopf, Sydney I. Ramirez, Jose Mateus, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Stephen A. Rawlings, Aaron Sutherland, Lakshmanane Premkumar, Ramesh S. Jadi, Daniel Marrama, Aravinda M. de Silva, April Frazier, Aaron F. Carlin, Jason A. Greenbaum, Bjoern Peters, Florian Krammer, Davey M. Smith, Shane Crotty, and Alessandro Sette
May 14, 2020
Cell
La Jolla Institute for Immunology

“Highlights:

  • Epitope pools detect CD4+ and CD8+ T cells in 100% and 70% of convalescent COVID patients
  • T cell responses are focused not only on spike but also on M, N, and other ORFs
  • T cell reactivity to SARS-CoV-2 epitopes is also detected in non-exposed individuals

Summary: … Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ∼40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2.”

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