"... Based on early clinical trial data, these [mRNA-LNP COVID-19] vaccines were deemed safe and effective for all demographics. However, the latest data raise serious concerns about the safety and effectiveness of these vaccines. Here, we review some of the safety and efficacy concerns identified to date. We also discuss the potential mechanism of observed adverse events related to the use of these vaccines and whether they can be mitigated by alterations of this vaccine mechanism approach.
The standard and non-standard components of the mRNA-LNP COVID-19 vaccines
... [A] recent preprint study using multiple sequencing assays reported levels of DNA contamination in both Moderna and Pfizer bivalent mRNA vaccines that exceeded the levels set by the European Medicines Agency (EMA) and The United States Food and Drug Administration (FDA)...
[T]he critical component that transformed the mRNA into an immune response-inducing vaccine is the inflammatory LNP – initially thought to be an inert carrier/delivery vehicle for mRNA – and not the nucleoside modifications.
Different levels of contaminants between vaccine lots, besides storage, transportation, and clinical handling, might explain a recent finding from Denmark that different lots of the mRNA Pfizer vaccines induced distinct levels of adverse events. Some lots caused almost no side effects, while others were associated with a medium or very high incidence of adverse events (all suspected side effects, -serious and -related deaths)...
Concerning assumptions made regarding the mRNA-LNP platform
... Because the mRNA can enter the nucleus, where it might be reverse-transcribed into DNA, this increases its potential to integrate into the genome. Furthermore, the mRNA-LNP diffuses throughout the body and can accumulate in both the testes and ovaries and is reported to alter the menstrual cycle in women. Therefore, it could potentially be reaching the stem cells of the reproductive organs...
How safe and effective are the mRNA-LNP vaccines?
... [R]ecent peer-reviewed research studies, a wide variety of continuously increasing case reports, and publicly available adverse events databases cast doubts on the safety and effectiveness of these products...
mRNA-LNP-associated adverse events – both inflammatory and inhibitory
The SAEs reported with the mRNA-LNP platform are very diverse. The SAEs are likely caused by the combination of the mRNA-LNP vaccine components and potentially by direct toxicity and biological action of the spike protein itself...
Brain Bites
Several fundamental questions persist surrounding the pandemic measures and the adoption of this new vaccine platform... For instance, reliance on official death toll statistics and not accounting for demographic variations in the virus infection fatality rate (IFR; the likelihood of death if you become infected) prompt questions about the accuracy of reported figures. Why did official statistics include both individuals who died from and with COVID-19? Why does the CDC estimate the flu-associated hospitalization and death for the adult population, arguing that it cannot be accurately determined but can give us exact numbers for COVID-19? Does the IFR data support the official death toll numbers?"
© 2024 Igyártó and Qin. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.