Case report with nude photos.
"Gigantomastia is a rare condition characterized by rapid, diffuse, and excessive breast growth. The etiology of gigantomastia is incompletely understood, but triggers have been classified into (1) idiopathic spontaneous growth, (2) endogenous hormone overproduction, and (3) pharmacological agents...
A known cause of gigantomastia is pseudoangiomatous stromal hyperplasia (PASH). PASH is characterized by idiopathic fibrous mammary stroma hyperplasia, typically associated with estrogen and progesterone overexpression. Most commonly, PASH manifests as incidental histological findings in the evaluation of breast lesions or as a palpable mass. There are fewer than 20 reports of PASH presenting as bilateral gigantomastia... This case is the first to demonstrate a temporal association between PASH-associated gigantomastia and a vaccine.
Case Report
A healthy, nulliparous 19-year-old woman experienced significant breast hypertrophy starting 1 week after receiving the Pfizer COVID-19 vaccine in September 2022. Her medical history was unremarkable, with no hormonal disturbances detected on bloodwork...
Discussion
After ruling out other potential causes, [the patient] underwent bilateral reduction mammoplasty, with histology revealing dense terminal duct lobular units interspersed with PASH.
The patient believed that the vaccine caused her breast growth; however, her concerns were not adequately addressed by her primary care physicians, leading to mistrust in the healthcare system."
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