The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

URL

https://www.sciencedirect.com/science/article/pii/S221287782300090X

Authors

Xiaoling Cao, Vi Nguyen, Joseph Tsai, Chao Gao, Yan Tian, Yuping Zhang, Wayne Carver, Hippokratis Kiaris, Taixing Cui, and Wenbin Tan

Published Date

June 20, 2023

Publication

Molecular Metabolism

Organization

University of South Carolina

Key Excerpts

"Background: ... This study aims to study whether the Spike protein plus obesity can exacerbate PASC-related cardiomyopathy...

Conclusion: Our data demonstrated that the Spike protein could induce long-term transcriptional suppression of mitochondria metabolic genes and cause cardiac fibrosis and myocardial contractile impairment in obese mice."

2023 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Topics

COVID-19,heart disorders,SARS-CoV-2 spike protein