Includes an overview of clinical studies for past SARS-CoV vaccines.
“Abstract: … Considering that antibody dependent enhancement (ADE) is a major obstacle in vaccine development, there are continued efforts to understand the underlying mechanisms through identification of the epitopes and antibodies responsible for disease enhancement or protection. This review discusses the recent findings on virally induced ADE, and highlights the potential mechanisms leading to this condition…
Coronaviruses: … Several studies have investigated the mechanisms underlying SARS-CoV mediated ADE.”
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